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Clinical Rehabilitation, Vol. 21, No. 7, 603-613 (2007)
DOI: 10.1177/0269215507075495
© 2007 SAGE Publications

Effects of an intensive rehabilitation programme on patients with Huntington's disease: a pilot study

Paola Zinzi

ISTC, National Research Council, Rome, paola.zinzi{at}istc.cnr.it

Dario Salmaso

ISTC, National Research Council, Rome and Padua

Rosa De Grandis

Home Care 'Nova Salus', Trasacco

Graziano Graziani

Home Care 'Nova Salus', Trasacco

Stefano Maceroni

Home Care 'Nova Salus', Trasacco

Annarita Bentivoglio

Institute of Neurology U.C.S.C., Rome

Paolo Zappata

Home Care 'Nova Salus', Trasacco

Marina Frontali

INMM, National Research Council, Rome

Gioia Jacopini

ISTC, National Research Council, Rome, Italy

Objective: To investigate the effects of an intensive, inpatient rehabilitation programme on individuals affected by Huntington's disease.

Design: A pilot study. Within-subjects design.

Setting: Inpatient rehabilitation home of the Italian welfare system.

Subjects: Forty patients, early and middle stage of the disease, were recruited to an intensive, inpatient rehabilitation protocol.

Interventions: The treatment programme included respiratory exercises and speech therapy, physical and occupational therapy and cognitive rehabilitation exercises. The programme involved three-week admission periods of intensive treatment that could be repeated three times a year.

Main measures: A standard clinical assessment was performed at the beginning of each admission using the Zung Depression Scale, Mini-Mental State Examination (MMSE), Barthel Index, Tinetti Scale and Physical Performance Test (PPT). Tinetti and PPT were also used at the end of each admission to assess the outcomes in terms of motor and functional performance.

Results: Each three-week period of treatment resulted in highly significant (P < 0.001) improvements of motor performance and daily life activities. The average increase was 4.7 for Tinetti and 5.21 for PPT scores. No carry-over effect from one admission to the next was apparent but at the same time, no motor decline was detected over two years, indicating that patients maintained a constant level of functional, cognitive as well as motor performance.

Conclusions: Intensive rehabilitation treatments may positively influence the maintenance of functional and motor performance in patients with Huntington's disease.


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