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Mortality and preoperative cardiac function in vascular amputees: an N-terminal pro-brain natriuretic peptide (NT-proBNP) pilot study

Center for Rehabilitation, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

Pieter U. Dijkstra

Center for Rehabilitation, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

Dirk Jan van Veldhuisen

Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

Frits A.J. Muskiet

Pathology and Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

Jan A.M.M. van den Dungen

Department of Vascular Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

Jan H.B. Geertzen

Center for Rehabilitation, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands, j.h.b.geertzen{at}rev.umcg.nl

Objective: To determine preoperative ventricular function in vascular amputees by measuring N-terminal pro-brain natriuretic peptide (NT-proBNP) and to analyse the relationship between NT-proBNP levels and 30-day postoperative mortality. Design: Prospective pilot study.

Subjects and methods: In 19 patients planned for a lower limb amputation for non-reconstructable peripheral arterial disease NT-proBNP was measured the day before amputation.

Results: Four amputees died within 30 days after the amputation. In 17 of 19 patients NT-proBNP values were found more than 2 standard deviations above the age corrected reference value. Pre-amputation NT-proBNP levels did not differ significantly between non-survivors and survivors (P = 0.162).

Conclusion: Preoperative NT-proBNP levels are not significantly related to 30-day mortality after lower limb amputation procedure. Preoperative NT-proBNP levels are very high, indicating that serious ventricular dysfunction may be present in vascular amputees.

This version was published on January 1, 2008

Clinical Rehabilitation, Vol. 22, No. 1, 56-59 (2008)
DOI: 10.1177/0269215507079864


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