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Clinical Rehabilitation
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A novel cause of intrathecal baclofen overdosage: lessons to be learnt

Catherine Dalton

National Hospital for Neurology and Neurosurgery, London, UK? Catherine.dalton{at}uclh.nhs.uk

Elizabeth Keenan

National Hospital for Neurology and Neurosurgery, London, UK

Val Stevenson

National Hospital for Neurology and Neurosurgery, London, UK

Case presentation: A serious intrathecal baclofen overdose occurred in a 45-year-old woman with primary progressive multiple sclerosis following a catheter dye study with concomitant change in baclofen concentration. The pump and catheter were emptied of baclofen 2000 µg/mL, refilled and primed with baclofen 1000 µg/mL. No correction was made for the `dead space' between the reservoir and catheter access port, which contained baclofen 2000 µg/mL. Failure of the priming bolus to account for the residual baclofen concentration within the dead space resulted in a serious overdose.

Action: Amendments are being made to both our local and the Medtronic protocols.

Conclusion: We hope that by reporting this incident the risk of this potentially fatal error re-occurring is minimized.

Clinical Rehabilitation, Vol. 22, No. 2, 188-190 (2008)
DOI: 10.1177/0269215507081962
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