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Influence of combined exercise training on indices of obesity, diabetes and cardiovascular risk in type 2 diabetes patients

Revalidation Sciences and Physiotherapy Ghent

Christophe Van Laethem

Revalidation Sciences and Physiotherapy Ghent

Kristien Van Acker

Sint Jozef Hospital, Bornem

Patrick Calders

Revalidation Sciences and Physiotherapy Ghent, Ghent, Belgium, patrick.calders{at}arteveldehs.be

Objective: To investigate the influence of combined exercise training on indices of obesity, diabetes and cardiovascular risk in type 2 diabetes patients.

Design: A double-blind randomized controlled trial with patients receiving either combination (COM), endurance (END) or no training (C).

Setting: Sint-Jozef hospital (Belgium), general practice (Holland).

Subjects: Forty-six type 2 diabetes patients (17 female, 29 male).

Interventions: COM versus END and C. Patients exercised for three months, three times a week for 1 hour.

Main measures: Six-minute walk test (6MW T), peak Vo₂, strength in upper and lower limbs, sit-to-stand, height, weight, body mass index, fat mass, glycosylated haemoglobin (HbA1c), glycaemia, triglycerides, high-density lipoprotein (HDL), total cholesterol and quality of life (General Health Survey Short Form (SF-36)).

Results: COM had significant better results on sit-to-stand (P<0.05), 6MW T (P<0.01), strength in upper (P<0.001) and lower limbs (P<0.001) compared with C. A different evolution among COM and C was found for HbA1c (P<0.05) and cholesterol (P<0.01), both decreased in COM and increased in C. HDL increased in COM and decreased in C (P<0.01). END had significant higher results on the 6MW T (P<0.01) compared with C. Compared with END, COM had significantly higher results on strength in upper (P<0.01) and lower limbs (P<0.01). The evolution of SF-36 items was not significantly different between the three groups.

Conclusion: In diabetes type 2 patients, COM had significant better effects on indices of physical condition, diabetes and cardiovascular risk compared with C. Compared with END, COM gave a tendency towards better results, however more research with a larger number of participants is needed.

Clinical Rehabilitation, Vol. 22, No. 6, 483-492 (2008)
DOI: 10.1177/0269215508084582


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