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Effect of Warm-Supplementing Kidney Yang (WSKY) added to risperidone on quality of life in patients with schizophrenia: a randomized controlled trialPsychiatry Department of Renmin Hospital of Wuhan University, Wuhan
Psychiatry Department of Renmin Hospital of Wuhan University, Wuhan, luochen67{at}21cn.com
Psychiatry Department of Renmin Hospital of Wuhan University, Wuhan
Youfu Hospital of Wuhan, Wuhan
Third Renmin Hospital of Jingmen of Hubei province, Jingmen
Psychiatry Department of Renmin Hospital of Wuhan University, Wuhan
Youfu Hospital of Wuhan, Wuhan, China Objective: To evaluate the quality of life, efficacy and safety of Warm-Supplementing Kidney Yang (WSKY) added to risperidone in patients with schizophrenia. Design: A randomized controlled trial. Setting: The outpatient and inpatient departments of three hospitals. Subjects: One hundred and twenty patients with clinically diagnosed schizophrenia with predominantly negative symptoms were included in the study. Intervention: All 120 patients were randomly assigned to double-blind treatment with WSKY group (n = 60) or placebo group (n = 60) added to risperidone for eight weeks. Main measure: The efficacy measures included the World Health Organization Quality of Life Scale (WHOQOL-100), the Positive and Negative Syndrome Scale (PANSS), the Social Disability Screening Schedule and the Hamilton Rating Scale for Depression. Safety and tolerability were assessed throughout the trial.
Results: The scores of quality of life in the WSKY group showed statistically significant improvement at the end-point of treatment compared with those in the placebo group (WSKY, increasing 40.5 (29.4); placebo, increasing 14.4 (27.1); F =24.900, P<0.001), while the scores of social function and depression symptoms also showed statistically significant improvement. The response rates for the WHOQOL-100 total scores were 50.0% for the WSKY group versus 31.7% for placebo group ( Conclusions: The results suggest that WSKY added to risperidone significantly improved the quality of life, social function, depression symptom compared with placebo added to risperidone.
This version was published on November
1, 2009 Clinical Rehabilitation, Vol. 23, No. 11,
963-972 (2009) |
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2 = 4.172, P=0.041). There were no significant differences in the safety/tolerability measures between the WSKY group and the placebo group during treatment.