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Clinical Rehabilitation, Vol. 9, No. 4, 331-338 (1995)
DOI: 10.1177/026921559500900409

Patterns of urine flow and electrolyte excretion in patients following traumatic brain injury

Stephen Novak

Regional Neurological Rehabilitation Unit, Homerton Hospital, London — King's College Hospital (Dulwich), East Dulwich Grove, London SE22 8PT, UK

Richard Greenwood

Regional Neurological Rehabilitation Unit, Homerton Hospital, London

This study was conducted to determine how commonly, following a traumatic brain injury (TBI), patients might lose their circadian rhythm of urine production and to explore possible causes. In health, an adult would be expected to have a daytime rate of urine production twice that of the night. Seven patients, all more than three months post-TBI, who were either continent or in whom continence could be achieved by use of an external device (convene) were investigated. For each patient, over a five-day period, the mean daytime and night-time rates of urine production were measured. These values were expressed as a ratio. In three of the seven patients this ratio did not differ significantly from 1, suggesting that they had lost their normal circadian rhythm of urine production. Screening of pituitary function implicated hypothalamic dysfunction in six of the seven patients, offering a possible explanation for the loss of circadian rhythm seen.


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S. Novak
Treatment with desmopressin in nocturia and nocturnal enuresis following traumatic brain injury
Clinical Rehabilitation, February 1, 1996; 10(1): 32 - 34.
[Abstract] [PDF]