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Clinical Rehabilitation
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Article

Mortality and preoperative cardiac function in vascular amputees: an N-terminal pro-brain natriuretic peptide (NT-proBNP) pilot study

Marcel Riemersma1, P Dijkstra2, Dirk Jan van Veldhuisen3, Frits A Muskiet4, Jan A van den Dungen5, and Jan HB Geertzen1*

1 Center for Rehabilitation
2 Department of Cardiology
3 Pathology and Laboratory Medicine
4 Department of Vascular Surgery
5 Center for Rehabilitation, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

* To whom correspondence should be addressed.


  Abstract

Objective: To determine preoperative ventricular function in vascular amputees by measuring N-terminal pro-brain natriuretic peptide (NT-proBNP) and to analyse the relationship between NT-proBNP levels and 30-day postoperative mortality.

Design: Prospective pilot study.

Subjects and methods: In 19 patients planned for a lower limb amputation for non-reconstructable peripheral arterial disease NT-proBNP was measured the day before amputation.

Results: Four amputees died within 30 days after the amputation. In 17 of 19 patients NT-proBNP values were found more than 2 standard deviations above the age corrected reference value. Pre-amputation NT-proBNP levels did not differ significantly between non-survivors and survivors (P = 0.162).

Conclusion: Preoperative NT-proBNP levels are not significantly related to 30-day mortality after lower limb amputation procedure. Preoperative NT-proBNP levels are very high, indicating that serious ventricular dysfunction may be present in vascular amputees.

First published on November 29, 2007, doi:10.1177/0269215507079864

Clinical Rehabilitation 2008;22:56.

A more recent version of this article appeared on January 1, 2008
 This version was published on December 5, 2007
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This article has been cited by other articles:


Home page
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T. Mueller, B. Dieplinger, W. Poelz, G. Endler, O. F. Wagner, and M. Haltmayer
Amino-Terminal Pro-B-Type Natriuretic Peptide as Predictor of Mortality in Patients with Symptomatic Peripheral Arterial Disease: 5-Year Follow-Up Data from the Linz Peripheral Arterial Disease Study
Clin. Chem., January 1, 2009; 55(1): 68 - 77.
[Abstract] [Full Text] [PDF]


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